Multiple mitochondrial alterations in a case of myopathy.
Ultrastruct Pathol
; 38(3): 204-10, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24579828
ABSTRACT
Mitochondrial alterations are the most common feature of human myopathies. A biopsy of quadriceps muscle from a 50-year-old woman exhibiting myopathic symptoms was examined by transmission electron microscopy. Biopsied fibers from quadriceps muscle displayed numerous subsarcolemmal mitochondria that contained crystalloids. Numbering 1-6 per organelle, these consisted of rows of punctuate densities measuring â¼0.34 nm; the parallel rows of these dots had a periodicity of â¼0.8 nm. The crystalloids were ensconced within cristae or in the outer compartment. Some mitochondria without crystalloids had circumferential cristae, leaving a membrane-free center that was filled with a farinaceous material. Other scattered fibrocyte defects included disruption of the contractile apparatus or its sporadic replacement by a finely punctuate material in some myofibers. Intramitochondrial crystalloids, although morphologically striking, do not impair organelle physiology to a significant degree, so the muscle weakness of the patient must originate elsewhere.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibras Musculares Esqueléticas
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Músculo Quadríceps
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Mitocôndrias Musculares
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Doenças Musculares
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article