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The fetal safety of Levetiracetam: a systematic review.
Chaudhry, Shahnaz Akhtar; Jong, Geert't; Koren, Gideon.
Afiliação
  • Chaudhry SA; The Motherisk Program, Division of Clinical Pharmacology & Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
  • Jong G; The Motherisk Program, Division of Clinical Pharmacology & Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
  • Koren G; The Motherisk Program, Division of Clinical Pharmacology & Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: gkoren@sickkids.ca.
Reprod Toxicol ; 46: 40-5, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24602560
OBJECTIVE: To systematically review the available published evidence on the fetal safety of Levetiracetam with focus on birth defects. RESULTS: Eight studies met the inclusion criteria; five pregnancy registries and one population based cohort study. A total of 27 major congenital malformations were reported among 1213 Levetiracetam monotherapy - exposed pregnant women, yielding an overall major malformation rate of 2.2% (27/1213) [95% confidence interval of 1.53-3.22]. In contrast, Levetiracetam polytherapy was associated with significantly higher malformation rate of 6.3% (34/541) [95% CI of 4.53-8.65] (P<0.001). Additionally 2 studies investigating child neurodevelopment in Levetiracetam - exposed children revealed that the measured achievements were well above those children exposed to valproic acid, and similar to unexposed controls. CONCLUSIONS: The current evidence suggests that the overall risk of major malformation after first trimester exposure to Levetiracetam is within the population baseline risk of 1-3%, with no apparent adverse effects on long term child development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piracetam / Doenças Fetais / Anticonvulsivantes Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piracetam / Doenças Fetais / Anticonvulsivantes Idioma: En Ano de publicação: 2014 Tipo de documento: Article