Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Leung, Justin W; Agarwal, Poonam; Canny, Marella D; Gong, Fade; Robison, Aaron D; Finkelstein, Ilya J; Durocher, Daniel; Miller, Kyle M

Leung, Justin W; Agarwal, Poonam; Canny, Marella D; Gong, Fade; Robison, Aaron D; Finkelstein, Ilya J; Durocher, Daniel; Miller, Kyle M.

Afiliação

Leung JW; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.
Agarwal P; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.
Canny MD; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Gong F; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.
Robison AD; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.
Finkelstein IJ; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.
Durocher D; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Miller KM; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, United States of America; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America.

PLoS Genet ; 10(3): e1004178, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24603765

Assuntos

Histonas/genética; Complexo Repressor Polycomb 1/genética; Ubiquitina-Proteína Ligases/genética; Ubiquitinação/genética; Proteínas de Ciclo Celular/metabolismo; Cromatina/metabolismo; Dano ao DNA/genética; Reparo do DNA; Proteínas de Ligação a DNA/genética; Células HEK293; Humanos; Nucleossomos/genética; Ligação Proteica/genética; Transdução de Sinais/genética; Ubiquitina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Ubiquitina-Proteína Ligases / Ubiquitinação / Complexo Repressor Polycomb 1 Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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