Adenosine and inflammation: what's new on the horizon?
Drug Discov Today
; 19(8): 1051-68, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24607729
ABSTRACT
Adenosine contributes to the maintenance of tissue integrity by modulating the immune system. Encouraging results have emerged with adenosine receptor ligands for the management of several inflammatory conditions in preclinical and clinical settings. However, therapeutic applications of these drugs are sometimes complicated by the occurrence of serious adverse effects. The scientific community is making intensive efforts to design novel adenosine receptor ligands endowed with greater selectivity or to develop innovative compounds acting as allosteric receptor modulators. In parallel, research is focusing on novel pharmacological entities (designated as adenosine-regulating agents) that can increase, in a site- and event-specific manner, adenosine concentrations at the inflammatory site, thereby minimizing the adverse systemic effects of adenosine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenosina
/
Inflamação
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article