Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation.
J Org Chem
; 79(7): 2843-53, 2014 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-24617567
ABSTRACT
Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Peptídeos Cíclicos
/
Compostos de Sulfidrila
/
Peptoides
/
Alcinos
/
Maleimidas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article