Allergen-specific IgE antibody serologic assays in patients with autoimmune pancreatitis.
Intern Med
; 53(6): 541-3, 2014.
Article
em En
| MEDLINE
| ID: mdl-24633022
ABSTRACT
OBJECTIVE:
To clarify the allergic manifestations in patients with autoimmune pancreatitis (AIP).METHODS:
We assessed 67 AIP patients, before they received steroid therapy, for a past history of allergic disease, the peripheral eosinophil count (n=62) and the serum IgE level (n=53). Allergen-specific IgE antibody serologic assays were performed in 15 patients.RESULTS:
A positive past history and/or the presence of active allergic disease were found in 24 AIP patients (36%), including 15 patients with acute allergic rhinitis and eight patients with bronchial asthma. Peripheral eosinophilia and elevation of the serum IgE level were detected in 16% (10/62) and 60% (32/53) of the patients, respectively. Allergen-specific IgE antibody serologic assays were positive in 13 patients (87%). There were no differences between the assay-positive and -negative patients regarding the clinical profiles.CONCLUSION:
In conclusion, 87% of the 15 AIP patients tested had positive allergen-specific IgE antibody serologic assays. Allergic mechanisms may be related to the occurrence of AIP.
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Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Asma
/
Imunoglobulina E
/
Alérgenos
/
Eosinófilos
/
Rinite Alérgica
/
Hipersensibilidade
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article