Complete pathological response to neoadjuvant pemetrexed/cisplatin in combination with regional hyperthermia in a patient with sarcomatoid peritoneal mesothelioma.
Anticancer Drugs
; 25(7): 854-6, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24637577
ABSTRACT
Diffuse malignant peritoneal mesothelioma (DMPM) is a rare disease. Although most patients eligible for surgery undergo cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy, the role of perioperative systemic chemotherapy still remains undefined. Here we report the case of a 52-year-old female patient with advanced sarcomatoid DMPM. After five cycles of systemic pemetrexed and cisplatin, along with two cycles of regional hyperthermia, tumor resection with histomorphological examination showed a complete pathological response. We therefore conclude that there is a subgroup of DMPM patients that might benefit from systemic neoadjuvant chemotherapy with pemetrexed and cisplatin.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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Sarcoma
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Protocolos de Quimioterapia Combinada Antineoplásica
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Terapia Neoadjuvante
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Hipertermia Induzida
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Mesotelioma
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article