Prognostic impact of genomic instability in colorectal cancer.
Br J Cancer
; 110(8): 2159-64, 2014 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-24642618
ABSTRACT
BACKGROUND:
The prognostic impact of an indication of chromosomal instability (CIN) is evaluated in a consecutive series of 952 colorectal cancer patients treated at Aker University Hospital, Norway, during 1993-2003. Microsatellite instability (MSI) in this case series has recently been reported and made it possible to find the co-occurrence and compare the prognostic significance of CIN and MSI.METHODS:
Data sets for overall survival (OS; n=855) and time to recurrence (TTR; n=579) were studied. To reveal CIN we used automated image cytometry (ICM). Non-diploid histograms were taken as indicative of the presence of CIN. PCR-based measures of MSI in this material have already been described.RESULTS:
As with MSI, CIN was found to be an independent predictor of early relapse and death among stage II patients (TTR n=278 HR 2.19 (95% CI 1.35-3.55), P=0.002). Of the MSI tumours (16%), 71% were found to be DNA diploid, 21% were DNA tetraploid and 8% were DNA aneuploid. Among microsatellite stable tumours, 24% were DNA diploid, 15% were DNA tetraploid and 61% were DNA aneuploid.CONCLUSION:
For patients presenting with stage II disease, genomic instability as detected by DNA image cytometry has the potential to provide a useful biomarker for relapse and cancer-related death following surgery with curative intent.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Prognóstico
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Neoplasias Colorretais
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Instabilidade de Microssatélites
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article