Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks.
Neuron
; 81(6): 1417-1428, 2014 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-24656258
ABSTRACT
Alzheimer's disease (AD) and semantic dementia (SD) are both characterized by severe atrophy in the hippocampus, a brain region underlying episodic memory; paradoxically, episodic memory is relatively preserved in SD. Here, we used intrinsic connectivity analyses and showed that the brain networks differentially vulnerable to each disease converge to the hippocampus in the healthy brain. As neurodegeneration is thought to spread within preexisting networks, the common hippocampal atrophy in both diseases is likely due to its location at the crossroad between both vulnerable networks. Yet, we showed that in the normal brain, these networks harbor different functions, with episodic memory relying on the AD-vulnerable network only. Overall, disease-associated cognitive deficits seem to reflect the disruption of targeted networks more than atrophy in specific brain regions in AD, over hippocampal atrophy, episodic memory deficits are likely due to disconnection within a memory-related network.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Demência Frontotemporal
/
Doença de Alzheimer
/
Hipocampo
/
Rede Nervosa
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article