Inhibitory effect of a novel naphthoquinone derivative on proliferation of vascular smooth muscle cells through suppression of platelet-derived growth factor receptor ß tyrosine kinase.

Kim, Yohan; Han, Joo-Hui; Yun, Eunju; Jung, Sang-Hyuk; Lee, Jung-Jin; Song, Gyu-Yong; Myung, Chang-Seon

Kim, Yohan; Han, Joo-Hui; Yun, Eunju; Jung, Sang-Hyuk; Lee, Jung-Jin; Song, Gyu-Yong; Myung, Chang-Seon.

Afiliação

Kim Y; Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehakno, Yuseong-gu, Daejeon 305-764, Republic of Korea.
Han JH; Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehakno, Yuseong-gu, Daejeon 305-764, Republic of Korea.
Yun E; Department of Medicinal Chemistry, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea.
Jung SH; Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehakno, Yuseong-gu, Daejeon 305-764, Republic of Korea.
Lee JJ; Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehakno, Yuseong-gu, Daejeon 305-764, Republic of Korea; Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea.
Song GY; Department of Medicinal Chemistry, Chungnam National University College of Pharmacy, Daejeon 305-764, Republic of Korea; Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea.
Myung CS; Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehakno, Yuseong-gu, Daejeon 305-764, Republic of Korea; Institute of Drug Research & Development, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: cm8r@cnu.ac.kr.

Eur J Pharmacol ; 733: 81-9, 2014 Jun 15.

Article em En | MEDLINE | ID: mdl-24695376

Assuntos

Proliferação de Células/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; Naftoquinonas/farmacologia; Receptor beta de Fator de Crescimento Derivado de Plaquetas/antagonistas & inibidores; Sulfonas/farmacologia; Animais; Aorta/efeitos dos fármacos; Aorta/enzimologia; Aorta/patologia; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; DNA/biossíntese; Immunoblotting; Músculo Liso Vascular/efeitos dos fármacos; Músculo Liso Vascular/enzimologia; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/enzimologia; Miócitos de Músculo Liso/patologia; Naftoquinonas/química; Fosforilação; Multimerização Proteica; Ratos; Transdução de Sinais/efeitos dos fármacos; Sulfonas/química

Palavras-chave

2-Undecylsulfonyl-DMNQ; Cardiovascular disease; Platelet-derived growth factor-receptor ß; Proliferation; Vascular smooth muscle cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Naftoquinonas / Receptor beta de Fator de Crescimento Derivado de Plaquetas / Miócitos de Músculo Liso / Proliferação de Células Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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