The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats.
Neurosci Lett
; 569: 137-41, 2014 May 21.
Article
em En
| MEDLINE
| ID: mdl-24704326
ABSTRACT
Research has shown that dopamine (DA) D3 receptors play a crucial role in cocaine addiction. Recently, there has been a strong focus on the development of DA D3 receptor antagonists as potential pharmacological treatments for cocaine addiction. We investigated the ability of a novel selective D3 receptor antagonist SR 21502 to block the expression of cocaine-induced conditioned place preference (CPP) in rats. CPP was determined using a two-chamber apparatus. All of the animals had free access to both chambers on day 1, followed by 4 alternating conditioning days of cocaine injection (paired chamber) and 4 alternating non-conditioning days with saline (non-paired chamber). On the test day, animals were systemically treated with 0, 3.75, 7.5 or 15mg/kg of SR 21502, 10min prior to being placed in the CPP apparatus, and the time spent in each chamber was recorded for 15min. The amount of time spent in the cocaine-paired chamber on the test and pre-exposure days was analyzed. Vehicle-treated animals spent significantly more time in the cocaine-paired side during the test than during the pre-exposure session, indicating a cocaine CPP. SR 21502 produced a dose-related significant reduction in the time spent in the cocaine-paired side compared to vehicle. The DA D3 receptor antagonist SR 21502 blocks the rat's preference for the cocaine-paired chamber, thereby attenuating the rewarding effect of the cocaine cues. This suggests that this compound may be an effective pharmacological treatment against cocaine addiction.
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MEDLINE
Assunto principal:
Piridinas
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Comportamento Animal
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Cocaína
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Condicionamento Clássico
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Comportamento de Procura de Droga
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Antagonistas dos Receptores de Dopamina D2
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Imidazóis
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article