Mitochondrial myopathy with dystrophic features due to a novel mutation in the MTTM gene.
Muscle Nerve
; 50(2): 292-5, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24711008
ABSTRACT
INTRODUCTION:
A 61-year-old woman with a 5-year history of progressive muscle weakness and atrophy had a muscle biopsy characterized by a combination of dystrophic features (necrotic fibers and endomysial fibrosis) and mitochondrial alterations [ragged-red, cytochrome c oxidase (COX)-negative fibers].METHODS:
Sequencing of the whole mtDNA, assessment of the mutation load in muscle and accessible nonmuscle tissues, and single fiber polymerase chain reaction.RESULTS:
Muscle mitochondrial DNA (mtDNA) sequencing revealed a novel heteroplasmic mutation (m.4403G>A) in the gene (MTTM) that encodes tRNA(Met). The mutation was not present in accessible nonmuscle tissues from the patient or 2 asymptomatic sisters.CONCLUSIONS:
The clinical features and muscle morphology in this patient are very similar to those described in a previous patient with a different mutation, also in MTTM, which suggests that mutations in this gene confer a distinctive "dystrophic" quality. This may be a diagnostic clue in patients with isolated mitochondrial myopathy.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
RNA de Transferência
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Miopatias Mitocondriais
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Distonia
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Mutação
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article