Pharyngeal spasticity due to dantrolene.
J Clin Pharm Ther
; 39(4): 449-51, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24725261
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene. CASESUMMARY:
A 12-year-old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity. After 5 days of full-dose dantrolene, his dysphagia worsened and he developed pharyngeal spasm. Dantrolene was suspected for an adverse reaction and removed. The patient subsequently improved. WHAT IS NEW ANDCONCLUSION:
Causality analysis determined a probable relationship between dantrolene and pharyngeal spasm. This may be due to direct muscle contraction by dantrolene, an effect seen previously in vitro.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Faríngeas
/
Dantroleno
/
Relaxantes Musculares Centrais
/
Espasticidade Muscular
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article