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Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
Boyce, Rogely W; Varela, Aurore; Chouinard, Luc; Bussiere, Jeanine L; Chellman, Gary J; Ominsky, Michael S; Pyrah, Ian T.
Afiliação
  • Boyce RW; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: rboyce@amgen.com.
  • Varela A; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: aurore.varela@crl.com.
  • Chouinard L; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: luc.chouinard@crl.com.
  • Bussiere JL; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: bussierj@amgen.com.
  • Chellman GJ; Charles River Preclinical Services-Nevada, 6995 Longley Lane, Reno, NV 89511, USA. Electronic address: gary.chellman@crl.com.
  • Ominsky MS; Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: mominsky@amgen.com.
  • Pyrah IT; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: ipyrah@amgen.com.
Bone ; 64: 314-25, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24727159
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Osteopetrose / Efeitos Tardios da Exposição Pré-Natal / Anticorpos Monoclonais Humanizados Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Osteopetrose / Efeitos Tardios da Exposição Pré-Natal / Anticorpos Monoclonais Humanizados Idioma: En Ano de publicação: 2014 Tipo de documento: Article