Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4.
JAMA Neurol
; 71(4): 495-8, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24733266
ABSTRACT
IMPORTANCE Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis. OBSERVATIONS In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department at Wayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation. CONCLUSIONS AND RELEVANCE This case extends the context of NMOSD as a paraneoplastic disorder.
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Base de dados:
MEDLINE
Assunto principal:
Tumor Carcinoide
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Neuromielite Óptica
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Síndromes Paraneoplásicas do Sistema Nervoso
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Aquaporina 4
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Neoplasias Intestinais
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Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article