Temporal changes of the adrenal endocrine system in a restraint stressed mouse and possibility of postmortem indicators of prolonged psychological stress.
Leg Med (Tokyo)
; 16(4): 193-6, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24735971
ABSTRACT
We investigated temporal changes of adrenal endocrine systems through the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenomedullary (SA) axis in restraint stressed mice. Restraint stress for 1 day to 3 weeks caused a significant increase in serum levels of ACTH and glucocorticoids accompanied with an increase in adrenal weights, indicating activation of the HPA axis. Reflecting the overproduction of glucocorticoids, adrenal cholesterol content decreased. Moreover, adrenal gene expression involved in cholesterol supply, including scavenger receptor-class B type I, HMG-CoA reductase, and hormone-sensitive lipase, was increased over the same period. After 4 weeks stress, all of these changes returned to control levels. In contrast, adrenal gene expression of chromogranin A, which is cosecreted with catecholamine via the SA axis, was increased with 1 day to 2 weeks of stress, and decreased with 3-4 weeks of stress. Our results suggest that analyses of adrenal endocrine systems based on the combination of several markers examined here would be useful for not only proving prolonged psychological stress experience but also determining its duration.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
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Estresse Fisiológico
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Estresse Psicológico
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Restrição Física
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Hormônio Adrenocorticotrópico
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Sistema Hipotálamo-Hipofisário
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article