Effect of age on response to palliative radiotherapy and quality of life in patients with painful bone metastases.
Radiother Oncol
; 111(2): 264-9, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24746581
ABSTRACT
BACKGROUND:
Multimorbidity and declining performance in elderly cancer patients may result in less treatment benefit. We investigated whether age is a predictor for pain response and quality of life (QoL) after radiotherapy in patients with painful bone metastases.METHODS:
The database of the Dutch Bone Metastasis Study was used (1996-1999). 1157 patients, irradiated for painful bone metastases, rated their pain, QoL-domains and overall health at baseline and during follow-up. Response was calculated taking into account changes in pain score and medication. Patients were grouped into three age cohorts A <65 (n=520), B 65-74 (n=410) and C ⩾75years (n=227).RESULTS:
No significant difference existed in pain response between cohorts 78% in cohort A, 74% in B and 67% in C. When assessing baseline QoL, a significant difference in activity level was noticed, with more impairment in elderly compared to younger patients (C versus B (p=0.01), C versus A (p<0.001)). Other QoL-domains were similar at baseline and during follow-up among cohorts. A pain response was significantly associated with improvement of health-related QoL (OR 3.74, 95% CI 2.66-5.25).CONCLUSION:
The majority of elderly patients with painful bone metastases responded to radiotherapy and showed comparable overall QoL compared to their younger counterparts. Age is not a predictor for pain response or QoL.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Dor
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Cuidados Paliativos
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Qualidade de Vida
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Neoplasias Ósseas
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Fatores Etários
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article