Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.

Bentinger, Magnus; Kania, Magdalena; Danikiewicz, Witold; Kaczorowska, Ewa; Wojcik, Jacek; Brismar, Kerstin; Dallner, Gustav; Chojnacki, Tadeusz; Swiezewska, Ewa; Tekle, Michael

Bentinger, Magnus; Kania, Magdalena; Danikiewicz, Witold; Kaczorowska, Ewa; Wojcik, Jacek; Brismar, Kerstin; Dallner, Gustav; Chojnacki, Tadeusz; Swiezewska, Ewa; Tekle, Michael.

Afiliação

Bentinger M; Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden; Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address: magnus.bentinger@dbb.su.se.
Kania M; Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
Danikiewicz W; Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
Kaczorowska E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Wojcik J; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Brismar K; Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden.
Dallner G; Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden; Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden.
Chojnacki T; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Swiezewska E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Tekle M; Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden; Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden.

Biochim Biophys Acta ; 1841(7): 977-86, 2014 Jul.

Article em En | MEDLINE | ID: mdl-24747199

Assuntos

Colesterol/análogos & derivados; Colesterol/biossíntese; Hemiterpenos/metabolismo; Compostos Organofosforados/metabolismo; Esqualeno/análogos & derivados; Ubiquinona/análogos & derivados; Animais; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Ácido Etidrônico/análogos & derivados; Ácido Etidrônico/farmacologia; Células Hep G2; Humanos; Lovastatina/farmacologia; Masculino; Ácido Mevalônico/farmacologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Ratos; Ratos Wistar; Ácido Risedrônico; Esqualeno/metabolismo; Esqualeno/farmacologia; Ácidos Tricarboxílicos/farmacologia; Ubiquinona/biossíntese

Palavras-chave

Cholesterol inhibition; Coenzyme Q induction; Dolichol; Mevalonate pathway; Squalene epoxides

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Esqualeno / Colesterol / Ubiquinona / Hemiterpenos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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