Stromal cell-derived factor-1-3'A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance.
J Cardiovasc Med (Hagerstown)
; 15(9): 710-6, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24751515
ABSTRACT
AIM:
Genome-wide association studies have identified single-nucleotide polymorphisms at the 10q11 locus as risk factors for myocardial infarction (MI). This locus lies upstream (â¼80âkb) of the stromal cell-derived factor-1 (SDF1) gene that codify for a chemokine with protective atherogenetic effects and with a major role in the mobilization, homing, and differentiation of endothelial progenitor cells (EPCs). The purpose of this study was to investigate the possible association of SDF1-3'A polymorphism, that upregulates SDF1 protein expression, with MI and early endothelial dysfunction and atherosclerosis in young healthy subjects.METHODS:
200 patients (181 men age 57.3â±â7.7 years) and 230 healthy controls (96 men, age 52â±â11.9 years) were recruited to investigate the association between MI and SDF1-3'A polymorphism. The relationship between SDF1-3'A polymorphism and brachial artery flow-mediated dilation and the number of circulating EPCs was examined in 50 healthy young adults.RESULTS:
A significant difference in SDF1-3'A genotype distribution was observed between patients and controls (Pâ=â0.006). Patients carrying the A allele had a significantly reduced MI risk compared with subjects with GG genotype (odds ratioâ=â0.5, 95% CIâ=â0.3-0.9, Pâ=â0.001). SDF1-3'A polymorphism presented a significant interaction with other cardiovascular risk factors (Pinteractionâ<â0. 0001). Controls carrying the A allele showed significantly higher flow-mediated dilation (13.9â±â4.9 vs 10.8â±â4.3, Pâ=â0.03) and significantly higher values of EPCs (0.029â±â0.009 vs 0.022â±â0.008, Pâ=â0.02) compared with GG homozygotes.CONCLUSION:
SDF1-3'A polymorphism is associated with a decreased risk of MI and early endothelial dysfunction, strongly confirming the important atherogenic role of SDF1 gene at clinical level.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
Quimiocina CXCL12
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article