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Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Krueger, Aaron B; Drasin, David J; Lea, Wendy A; Patrick, Aaron N; Patnaik, Samarjit; Backos, Donald S; Matheson, Christopher J; Hu, Xin; Barnaeva, Elena; Holliday, Michael J; Blevins, Melanie A; Robin, Tyler P; Eisenmesser, Elan Z; Ferrer, Marc; Simeonov, Anton; Southall, Noel; Reigan, Philip; Marugan, Juan; Ford, Heide L; Zhao, Rui.
Afiliação
  • Krueger AB; From the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Drasin DJ; the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Lea WA; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Patrick AN; the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Patnaik S; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Backos DS; the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, Colorado 80045.
  • Matheson CJ; the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, Colorado 80045.
  • Hu X; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Barnaeva E; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Holliday MJ; From the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Blevins MA; From the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Robin TP; the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Eisenmesser EZ; From the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
  • Ferrer M; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Simeonov A; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Southall N; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and.
  • Reigan P; the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, Colorado 80045.
  • Marugan J; the National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, and maruganj@mail.nih.gov.
  • Ford HL; the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, heide.ford@ucdenver.edu.
  • Zhao R; From the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, rui.zhao@ucdenver.edu.
J Biol Chem ; 289(23): 16349-61, 2014 Jun 06.
Article em En | MEDLINE | ID: mdl-24755226

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Movimento Celular / Proteínas Tirosina Fosfatases / Peptídeos e Proteínas de Sinalização Intracelular Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Movimento Celular / Proteínas Tirosina Fosfatases / Peptídeos e Proteínas de Sinalização Intracelular Idioma: En Ano de publicação: 2014 Tipo de documento: Article