Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism.

Kozina, Elena A; Khakimova, Gulnara R; Khaindrava, Vitaly G; Kucheryanu, Valeriayn G; Vorobyeva, Nadezhda E; Krasnov, Alexey N; Georgieva, Sophia G; Kerkerian-Le Goff, Lidiya; Ugrumov, Michael V

Kozina, Elena A; Khakimova, Gulnara R; Khaindrava, Vitaly G; Kucheryanu, Valeriayn G; Vorobyeva, Nadezhda E; Krasnov, Alexey N; Georgieva, Sophia G; Kerkerian-Le Goff, Lidiya; Ugrumov, Michael V.

Afiliação

Kozina EA; Laboratory of Hormonal Regulations, Institute of Developmental Biology RAS, Moscow, Russia; Laboratory of Neurohistology, Institute of Normal Physiology RAMS, Moscow, Russia.
Khakimova GR; Laboratory of Hormonal Regulations, Institute of Developmental Biology RAS, Moscow, Russia; Laboratory of Neurohistology, Institute of Normal Physiology RAMS, Moscow, Russia.
Khaindrava VG; Laboratory of Neurohistology, Institute of Normal Physiology RAMS, Moscow, Russia; IC2N, IBDML, UMR6216 CNRS-Université de la Méditerranée, Marseille, France.
Kucheryanu VG; Laboratory of General Pathophysiology of Nervous System, Institute of General Pathology and Pathological Physiology, RAMS, Moscow, Russia.
Vorobyeva NE; Laboratory of Gene Expression Regulation, Institute of Gene Biology RAS, Moscow, Russia.
Krasnov AN; Laboratory of Gene Expression Regulation, Institute of Gene Biology RAS, Moscow, Russia.
Georgieva SG; Laboratory of Gene Expression Regulation, Institute of Gene Biology RAS, Moscow, Russia.
Kerkerian-Le Goff L; IC2N, IBDML, UMR6216 CNRS-Université de la Méditerranée, Marseille, France.
Ugrumov MV; Laboratory of Hormonal Regulations, Institute of Developmental Biology RAS, Moscow, Russia; Laboratory of Neurohistology, Institute of Normal Physiology RAMS, Moscow, Russia. Electronic address: michael.ugrumov@mail.ru.

J Neurol Sci ; 340(1-2): 198-207, 2014 May 15.

Article em En | MEDLINE | ID: mdl-24768159

Assuntos

Corpo Estriado/patologia; Neurônios Dopaminérgicos/fisiologia; Intoxicação por MPTP/patologia; Intoxicação por MPTP/fisiopatologia; Substância Negra/patologia; Tirosina 3-Mono-Oxigenase/metabolismo; Animais; Inibidores das Descarboxilases de Aminoácidos Aromáticos/farmacologia; Modelos Animais de Doenças; Dopamina/metabolismo; Eletroquímica; Regulação da Expressão Gênica/efeitos dos fármacos; Hidrazinas/farmacologia; Levodopa/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Atividade Motora/efeitos dos fármacos; Atividade Motora/fisiologia; RNA Mensageiro/metabolismo; Tirosina 3-Mono-Oxigenase/genética

Palavras-chave

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Mice; Nigrostriatal system; Parkinson's disease; Tyrosine hydroxylase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina 3-Mono-Oxigenase / Substância Negra / Corpo Estriado / Intoxicação por MPTP / Neurônios Dopaminérgicos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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