Causal prophylactic efficacy of primaquine, tafenoquine, and atovaquone-proguanil against Plasmodium cynomolgi in a rhesus monkey model.
J Parasitol
; 100(5): 671-3, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24780070
ABSTRACT
Since the 1940s, the large animal model to assess novel causal prophylactic antimalarial agents has been the Plasmodium cynomolgi sporozoite-infected Indian-origin rhesus monkey. In 2009 the model was reassessed with 3 clinical standards primaquine (PQ), tafenoquine (TQ), and atovaquone-proguanil. Both control monkeys were parasitemic on day 8 post-sporozoite inoculation on day 0. Primaquine at 1.78 mg base/kg/day on days (-1) to 8 protected 1 monkey and delayed parasitemia patency of the other monkey to day 49. Tafenoquine at 6 mg base/kg/day on days (-1) to 1 protected both monkeys. However, atovaquone-proguanil at 10 mg atovaquone/kg/day on days (-1) to 8 did not protect either monkey and delayed patency only to days 18-19. Primaquine and TQ at the employed regimens are proposed as appropriate doses of positive control drugs for the model at present.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Primaquina
/
Proguanil
/
Plasmodium cynomolgi
/
Atovaquona
/
Aminoquinolinas
/
Malária
/
Antimaláricos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article