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Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity.
Chu, YunXiang; Fioravante, Diasynou; Leitges, Michael; Regehr, Wade G.
Afiliação
  • Chu Y; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
  • Fioravante D; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
  • Leitges M; The Biotechnology Centre of Oslo, University of Oslo, Forskningsparken, Gaustadalléen 21, 0349 Oslo, Norway.
  • Regehr WG; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: wade_regehr@hms.harvard.edu.
Neuron ; 82(4): 859-71, 2014 May 21.
Article em En | MEDLINE | ID: mdl-24794094
ABSTRACT
Posttetanic potentiation (PTP) is a widely observed form of short-term plasticity lasting for tens of seconds after high-frequency stimulation. Here we show that although protein kinase C (PKC) mediates PTP at the calyx of Held synapse in the auditory brainstem before and after hearing onset, PTP is produced primarily by an increased probability of release (p) before hearing onset, and by an increased readily releasable pool of vesicles (RRP) thereafter. We find that these mechanistic differences, which have distinct functional consequences, reflect unexpected differential actions of closely related calcium-dependent PKC isoforms. Prior to hearing onset, when PKCγ and PKCß are both present, PKCγ mediates PTP by increasing p and partially suppressing PKCß actions. After hearing onset, PKCγ is absent and PKCß produces PTP by increasing RRP. In hearing animals, virally expressed PKCγ overrides PKCß to produce PTP by increasing p. Thus, two similar PKC isoforms mediate PTP in distinctly different ways.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Proteína Quinase C / Ponte / Isoformas de Proteínas / Neurônios Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Proteína Quinase C / Ponte / Isoformas de Proteínas / Neurônios Idioma: En Ano de publicação: 2014 Tipo de documento: Article