Deciphering functions of branched ubiquitin chains.
Cell
; 157(4): 767-9, 2014 May 08.
Article
em En
| MEDLINE
| ID: mdl-24813601
ABSTRACT
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexo de Endopeptidases do Proteassoma
/
Proteólise
/
Ciclossomo-Complexo Promotor de Anáfase
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article