Interferon beta treatment of multiple sclerosis increases serum interleukin-7.
Mult Scler
; 20(13): 1727-36, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24821684
ABSTRACT
BACKGROUND:
Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically and functionally associated with several autoimmune diseases including multiple sclerosis (MS).OBJECTIVE:
The objective of this paper is to elucidate the effect of the widely used immunomodulatory MS therapy interferon beta (IFNß) on IL-7 homeostasis.METHODS:
Swedish MS patients were screened for IL-7 concentration in serum and blood cell counts. IL-7 receptor alpha chain (IL-7Rα) expression was determined by semi-quantitative real-time polymerase chain reaction (PCR) and flow cytometry.RESULTS:
IFNß treatment led to significantly increased serum IL-7 levels (mean 17 pg/ml) compared with healthy controls (mean 7.6 pg/ml) and natalizumab-treated patients (mean 5.3 pg/ml). In vitro and in vivo, peripheral blood leukocytes showed decreased IL-7Rα expression and IL-7 consumption upon IFNß exposure, suggesting that their IL-7 responsiveness is impaired during treatment.CONCLUSIONS:
MS patients undergoing IFNß treatment have increased serum IL-7 levels and decreased IL-7 consumption. Given IL-7's important role in T-cell immunity, this relationship may be highly relevant for IFNß's treatment efficacy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Interleucina-7
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Interferon beta
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Imunossupressores
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article