Synthesis and potent ionophoric activity of a squaramide-linked bis(choloyl) conjugate.
Bioorg Med Chem Lett
; 24(13): 2859-62, 2014 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-24835981
ABSTRACT
A squaramide-linked bis(choloyl) conjugate was synthesized and fully characterized on the basis of NMR ((1)H and (13)C) and ESI MS (LR and HR) data. Fluorescence and chloride ion selective electrode assays indicate that this compound exhibits potent ionophoric activity across egg-yolk L-α-phosphatidylcholine-based liposomal membranes, presumably via an anion-modulating anion-cation co-transport/symport process. A Hill analysis reveals that three molecules of this compound are assembled into the transport-active species.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Cólicos
/
Amidas
/
Ionóforos
/
Lipossomos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article