Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.
Gen Thorac Cardiovasc Surg
; 64(3): 167-9, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-24846683
ABSTRACT
We herein present a rare case of ALK-positive pulmonary pleomorphic carcinoma in an octogenarian patient. A computed tomography scan of the thorax indicated a pulmonary nodule in the right upper lobe of an asymptomatic 87-year-old female. The surgical resection revealed that the disease was pleomorphic carcinoma with pathological T2aN0M0, stage IB. EML4-ALK was evaluated using immunohistochemistry and fluorescence in situ hybridization, and EGFR mutations were analyzed using the Cycleave method. While there were no EGFR mutations detected, she was positive for the ALK rearrangement. This is the first report of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.
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MEDLINE
Assunto principal:
DNA de Neoplasias
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Adenocarcinoma
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Receptores Proteína Tirosina Quinases
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Neoplasias Pulmonares
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Mutação
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article