Gonadotropin-dependent precocious puberty in an 8-year-old boy with leydig cell testicular tumor.
Horm Res Paediatr
; 82(2): 133-7, 2014.
Article
em En
| MEDLINE
| ID: mdl-24862970
ABSTRACT
Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
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Neoplasias Testiculares
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Hormônio Liberador de Gonadotropina
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Tumor de Células de Leydig
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article