Sequential direct SNAr reactions of pentafluorobenzenes with azole or indole derivatives.
Org Lett
; 16(11): 3130-3, 2014 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-24869660
ABSTRACT
Sequential regioselective N-arylations through high-yielding catalyst-free direct SNAr reactions of pentafluorobenzene derivatives with azole or indole derivatives are described. The N-arylated derivatives were further functionalized through a microwave-assisted cross-coupling reaction via C-H bond activation or Suzuki conditions. The order of the reactions could be reversed, proving full orthogonality between the reactions which led to well-defined fully substituted benzene derivatives.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Derivados de Benzeno
/
Fluorbenzenos
/
Indóis
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article