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The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Garbers, Christoph; Monhasery, Niloufar; Aparicio-Siegmund, Samadhi; Lokau, Juliane; Baran, Paul; Nowell, Mari A; Jones, Simon A; Rose-John, Stefan; Scheller, Jürgen.
Afiliação
  • Garbers C; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Institute of Biochemistry, Christian-Albrechts-University, Olshausenstraße 40, Kiel, Germany.
  • Monhasery N; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
  • Aparicio-Siegmund S; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
  • Lokau J; Institute of Biochemistry, Christian-Albrechts-University, Olshausenstraße 40, Kiel, Germany.
  • Baran P; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
  • Nowell MA; Institute of Infection and Immunity, The School of Medicine, Cardiff University, Cardiff, CF14 4XN Wales, United Kingdom.
  • Jones SA; Institute of Infection and Immunity, The School of Medicine, Cardiff University, Cardiff, CF14 4XN Wales, United Kingdom.
  • Rose-John S; Institute of Biochemistry, Christian-Albrechts-University, Olshausenstraße 40, Kiel, Germany.
  • Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: jscheller@uni-duesseldorf.de.
Biochim Biophys Acta ; 1842(9): 1485-94, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24878322
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Interleucina-6 / Polimorfismo de Nucleotídeo Único / Proteínas ADAM / Secretases da Proteína Precursora do Amiloide / Células Precursoras de Linfócitos B / Proteólise / Fibroblastos / Proteínas de Membrana Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Interleucina-6 / Polimorfismo de Nucleotídeo Único / Proteínas ADAM / Secretases da Proteína Precursora do Amiloide / Células Precursoras de Linfócitos B / Proteólise / Fibroblastos / Proteínas de Membrana Idioma: En Ano de publicação: 2014 Tipo de documento: Article