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Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach.
Hwang, Jin-Hee; Lee, Kyu-Sup; Joo, Jong-Kil; Wang, Tao; Son, Jung-Bin; Park, Jong-Ha; Hwang, Dae-Youn; Choi, Man-Ho; Lee, Hong-Gu.
Afiliação
  • Hwang JH; Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143­701, South Korea.
  • Lee KS; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
  • Joo JK; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
  • Wang T; Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143­701, South Korea.
  • Son JB; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
  • Park JH; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea.
  • Hwang DY; Department of Biomaterial Science, College of Natural Resources and Life Science, Pusan National University, Miryang 627-706, South Korea.
  • Choi MH; Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, South Korea.
  • Lee HG; Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143­701, South Korea.
Mol Med Rep ; 10(2): 725-30, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24889313
ABSTRACT
The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Proteômica / Endometriose Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Proteômica / Endometriose Idioma: En Ano de publicação: 2014 Tipo de documento: Article