Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

Tang, Haifeng; Walsh, Shawn P; Yan, Yan; de Jesus, Reynalda K; Shahripour, Aurash; Teumelsan, Nardos; Zhu, Yuping; Ha, Sookhee; Owens, Karen A; Thomas-Fowlkes, Brande S; Felix, John P; Liu, Jessica; Kohler, Martin; Priest, Birgit T; Bailey, Timothy; Brochu, Richard; Alonso-Galicia, Magdalena; Kaczorowski, Gregory J; Roy, Sophie; Yang, Lihu; Mills, Sander G; Garcia, Maria L; Pasternak, Alexander

Tang, Haifeng; Walsh, Shawn P; Yan, Yan; de Jesus, Reynalda K; Shahripour, Aurash; Teumelsan, Nardos; Zhu, Yuping; Ha, Sookhee; Owens, Karen A; Thomas-Fowlkes, Brande S; Felix, John P; Liu, Jessica; Kohler, Martin; Priest, Birgit T; Bailey, Timothy; Brochu, Richard; Alonso-Galicia, Magdalena; Kaczorowski, Gregory J; Roy, Sophie; Yang, Lihu; Mills, Sander G; Garcia, Maria L; Pasternak, Alexander.

Afiliação

Tang H; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Walsh SP; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Yan Y; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
de Jesus RK; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Shahripour A; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Teumelsan N; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Zhu Y; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Ha S; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Owens KA; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Thomas-Fowlkes BS; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Felix JP; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Liu J; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Kohler M; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Priest BT; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Bailey T; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Brochu R; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Alonso-Galicia M; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Kaczorowski GJ; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Roy S; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Yang L; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Mills SG; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Garcia ML; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.
Pasternak A; Departments of Medicinal Chemistry, Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories , Rahway New Jersey 07065, United States.