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Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
Cardellina, John H; Roxas-Duncan, Virginia I; Montgomery, Vicki; Eccard, Vanessa; Campbell, Yvette; Hu, Xin; Khavrutskii, Ilja; Tawa, Gregory J; Wallqvist, Anders; Gloer, James B; Phatak, Nisarga L; Höller, Ulrich; Soman, Ashish G; Joshi, Biren K; Hein, Sara M; Wicklow, Donald T; Smith, Leonard A.
Afiliação
  • Cardellina JH; Division of Integrated Toxicology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
  • Roxas-Duncan VI; Division of Integrated Toxicology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
  • Montgomery V; Division of Integrated Toxicology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
  • Eccard V; Division of Integrated Toxicology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
  • Campbell Y; Division of Integrated Toxicology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
  • Hu X; Biotechnology High Performance Computer Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command , Frederick, Maryland 21702.
  • Khavrutskii I; Biotechnology High Performance Computer Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command , Frederick, Maryland 21702.
  • Tawa GJ; Biotechnology High Performance Computer Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command , Frederick, Maryland 21702.
  • Wallqvist A; Biotechnology High Performance Computer Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command , Frederick, Maryland 21702.
  • Gloer JB; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Phatak NL; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Höller U; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Soman AG; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Joshi BK; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Hein SM; Department of Chemistry, University of Iowa , Iowa City, Iowa 52242-1294.
  • Wicklow DT; Bacterial Foodborne Pathogens and Mycology Research Unit, Agricultural Research Service, U.S. Department of Agriculture , Peoria, Illinois 61604.
  • Smith LA; Senior Research Scientist for Medical Countermeasures Technology, U.S. Army Medical Research Institute of Infectious Diseases , Frederick, Maryland 21702-5011.
ACS Med Chem Lett ; 3(5): 387-91, 2012 May 10.
Article em En | MEDLINE | ID: mdl-24900483
ABSTRACT
An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of ∼350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neurotoxin serotype A (BoNT A). Subsequent acquisition and testing of analogues of 1 uncovered two compounds, talaroderxines A (2) and B (3), with improved activity. These are the first fungal metabolites reported to exhibit BoNT/A inhibitory activity.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article