Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.
Chem Commun (Camb)
; 50(58): 7800-2, 2014 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-24903342
ABSTRACT
A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pargilina
/
Propilaminas
/
Isotiocianatos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article