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Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
Walsh, Kyle M; Codd, Veryan; Smirnov, Ivan V; Rice, Terri; Decker, Paul A; Hansen, Helen M; Kollmeyer, Thomas; Kosel, Matthew L; Molinaro, Annette M; McCoy, Lucie S; Bracci, Paige M; Cabriga, Belinda S; Pekmezci, Melike; Zheng, Shichun; Wiemels, Joseph L; Pico, Alexander R; Tihan, Tarik; Berger, Mitchell S; Chang, Susan M; Prados, Michael D; Lachance, Daniel H; O'Neill, Brian Patrick; Sicotte, Hugues; Eckel-Passow, Jeanette E; van der Harst, Pim; Wiencke, John K; Samani, Nilesh J; Jenkins, Robert B; Wrensch, Margaret R.
Afiliação
  • Walsh KM; 1] Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
  • Codd V; 1] Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  • Smirnov IV; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Rice T; Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Decker PA; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Hansen HM; Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Kollmeyer T; Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Kosel ML; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Molinaro AM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • McCoy LS; Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Bracci PM; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Cabriga BS; Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Pekmezci M; Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
  • Zheng S; Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Wiemels JL; 1] Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. [3] Institute for Human Genetics,
  • Pico AR; 1] Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Department of Bioinformatics, Gladstone Institutes, San Francisco, California, USA.
  • Tihan T; Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
  • Berger MS; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Chang SM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Prados MD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Lachance DH; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • O'Neill BP; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Sicotte H; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Eckel-Passow JE; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • van der Harst P; 1] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [2] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Wiencke JK; 1] Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.
  • Samani NJ; 1] Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  • Jenkins RB; Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Wrensch MR; 1] Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.
Nat Genet ; 46(7): 731-5, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24908248
ABSTRACT
Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between LTL and both this new risk locus and other previously established risk loci for glioma using data from a recent GWAS of LTL (n = 37,684 individuals). Alleles associated with glioma risk near TERC and TERT were strongly associated with longer LTL (P = 5.5 × 10(-20) and 4.4 × 10(-19), respectively). In contrast, risk-associated alleles near RTEL1 were inconsistently associated with LTL, suggesting the presence of distinct causal alleles. No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / Telômero / Telomerase / Polimorfismo de Nucleotídeo Único / Glioma Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / Telômero / Telomerase / Polimorfismo de Nucleotídeo Único / Glioma Idioma: En Ano de publicação: 2014 Tipo de documento: Article