Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents.
Org Biomol Chem
; 12(28): 5212-21, 2014 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-24914508
ABSTRACT
Diastereoselective autoxidation allowed preparation of new tricyclic endoperoxides. These compounds and their methylated analogs were evaluated against the in vitro growth of Plasmodium falciparum, the malaria-causing parasite, showing moderate activities. However, hybrid molecules composed of the tricyclic peroxide moiety and 7-chloro-4-aminoquinoline were synthesized and displayed a marked increase in antiplasmodial activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peróxidos
/
Plasmodium falciparum
/
Radicais Livres
/
Aminoquinolinas
/
Ferro
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Antimaláricos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article