Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.
Front Cell Infect Microbiol
; 4: 76, 2014.
Article
em En
| MEDLINE
| ID: mdl-24926442
ABSTRACT
Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Lyme
/
Borrelia burgdorferi
/
Suscetibilidade a Doenças
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article