Stereoselective α-fluorination of N-acyloxazolidinones at room temperature within 1 h.
J Org Chem
; 79(13): 6206-20, 2014 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-24926887
ABSTRACT
A direct α-fluorination of N-acyloxazolidinones based on the unique reactivity of group IVa metal enolates has been developed. The reaction is an experimentally simple, low-cost, quick, and energy-efficient alternative for asymmetric α-fluorination of N-acyloxazolidinones. Preliminary studies have shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromatic substituents. High diastereoselectivities have been achieved with most substrates tested, and the reaction is typically complete within 1 h at ambient temperature.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxazolidinonas
/
Alcenos
/
Alcinos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article