Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration.
FEBS Lett
; 588(17): 2985-92, 2014 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-24928273
ABSTRACT
The mitochondrial respiratory chain is essential for the conversion of energy derived from the oxidation of metabolites into the membrane potential, which drives the synthesis of ATP. The electron transporting complexes bc1 complex and the cytochrome c oxidase assemble into large supercomplexes, allowing efficient energy transduction. Currently, we have only limited information about what determines the structure of the supercomplex. Here, we characterize Aim24 in baker's yeast as a protein, which is integrated in the mitochondrial inner membrane and is required for the structural integrity of the supercomplex. Deletion of AIM24 strongly affects activity of the respiratory chain and induces a growth defect on non-fermentable medium. Our data indicate that Aim24 has a function in stabilizing the respiratory chain supercomplexes.
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MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Proteínas de Saccharomyces cerevisiae
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Complexo de Proteínas da Cadeia de Transporte de Elétrons
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article