Preclinical evaluation of efficacy and stability of docetaxel micelle-encapsulated by a tripodal cyclotriphosphazene amphiphile.

Chae, Song Wha; Jun, Yong Joo; Cui, Jin Xin; Park, Jung Hyun; Lee, Hwa Jeong; Sohn, Youn Soo

Chae, Song Wha; Jun, Yong Joo; Cui, Jin Xin; Park, Jung Hyun; Lee, Hwa Jeong; Sohn, Youn Soo.

Afiliação

Chae SW; Division of Life and Pharmaceutical Sciences & College of Pharmacy (Global Top 5 Research Program), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: yuki1226@naver.com.
Jun YJ; C & Pharm, Rm B211, Science Building B, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: yjjun23@hanmail.net.
Cui JX; C & Pharm, Rm B211, Science Building B, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: cjxybu04@126.com.
Park JH; Division of Life and Pharmaceutical Sciences & College of Pharmacy (Global Top 5 Research Program), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: 10239@hanmail.net.
Lee HJ; Division of Life and Pharmaceutical Sciences & College of Pharmacy (Global Top 5 Research Program), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: hwalee@ewha.ac.kr.
Sohn YS; C & Pharm, Rm B211, Science Building B, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Republic of Korea. Electronic address: yssohn@ewha.ac.kr.

Biomed Pharmacother ; 68(5): 649-55, 2014 Jun.

Article em En | MEDLINE | ID: mdl-24930885

Assuntos

Avaliação Pré-Clínica de Medicamentos; Micelas; Compostos Organofosforados/uso terapêutico; Peptídeos/uso terapêutico; Polietilenoglicóis/uso terapêutico; Tensoativos/uso terapêutico; Taxoides/uso terapêutico; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Peso Corporal/efeitos dos fármacos; Docetaxel; Estabilidade de Medicamentos; Feminino; Masculino; Camundongos Nus; Compostos Organofosforados/farmacocinética; Compostos Organofosforados/farmacologia; Peptídeos/química; Peptídeos/farmacocinética; Peptídeos/farmacologia; Polietilenoglicóis/química; Polietilenoglicóis/farmacocinética; Polietilenoglicóis/farmacologia; Ratos Sprague-Dawley; Soluções; Tensoativos/farmacologia; Taxoides/farmacologia; Fatores de Tempo; Distribuição Tecidual/efeitos dos fármacos; Resultado do Tratamento; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Anticancer drug; Cyclotriphosphazene; Docetaxel; Drug delivery; Polymeric micelle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Peptídeos / Polietilenoglicóis / Tensoativos / Taxoides / Avaliação Pré-Clínica de Medicamentos / Micelas Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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