The impact of body mass index on renal functional outcomes following minimally invasive partial nephrectomy.
J Endourol
; 28(11): 1338-44, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24935823
ABSTRACT
OBJECTIVE:
To assess the impact of body mass index (BMI) on perioperative and renal functional outcomes in patients undergoing minimally invasive partial nephrectomy (MIPN). MATERIALS ANDMETHODS:
In our IRB-approved, prospectively maintained clinical database, we identified 1206 patients who underwent kidney surgery from 2002 to 2013. Estimated glomerular filtration rate (eGFR) was obtained at baseline and each follow-up visit. From this group, patients who underwent MIPN with more than 12 months of follow-up were selected. Patients were separated into 4 cohorts based on BMI normal weight (<25 kg/m(2)), preobese (25-30 kg/m(2)), obese class 1 (30-35 kg/m(2)), and obese class ≥2 (>35 kg/m(2)). Change in eGFR was compared across demographic and clinical variables through linear and logistic regression models.RESULTS:
A total of 235 patients met inclusion criteria with median follow-up of 29 months (interquartile range [IQR] 19, 45). There were no differences in demographic, perioperative, or pathologic features between BMI groups. While controlling for gender, race, Charlson comorbidity score, tumor size, and ischemia time, obese class 1 (odds ratio [OR] 4.68, p=0.019), obese class ≥2 (OR 4.27, p=0.033), and age (OR 1.06, p=0.014) were associated with increased risk of CKD stage ≥3; however, higher baseline eGFR (OR 0.91, p<0.001) was associated with a reduced risk of CKD stage ≥3. While controlling for the same variables, increasing BMI was associated with a significant absolute reduction in eGFR at 1 year (0.38 mL/minute/1.73 m(2) reduction in GFR per 1 kg/m(2) increase in BMI, p=0.009).CONCLUSIONS:
MIPN is technically feasible in obese patients with similar perioperative outcomes to nonobese patients. BMI is an independent risk factor for worsening kidney function following MIPN.
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Base de dados:
MEDLINE
Assunto principal:
Índice de Massa Corporal
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Insuficiência Renal Crônica
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Neoplasias Renais
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Nefrectomia
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Obesidade
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article