Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1ß, IL-6 and IL-10 on human macrophages.
Inflamm Res
; 63(9): 769-78, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24947163
ABSTRACT
OBJECTIVE:
Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages.METHODS:
The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages.RESULTS:
LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1ß, IL-6 and IL-10. The production of TNF-α was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-κB or p38 MAPK activation.CONCLUSION:
TTO, terpinen-4-ol and alpha-terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Citocinas
/
Óleo de Melaleuca
/
Monoterpenos
/
Cicloexenos
/
Macrófagos
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article