[Association of red blood cell and platelet allo-antibodies in platelet alloimmunized patients]. / Association d'allo-anticorps anti-érythrocytaires et anti-plaquettes chez les patients avec allo-immunisation anti-plaquettaire.
Transfus Clin Biol
; 21(3): 99-102, 2014 Jun.
Article
em Fr
| MEDLINE
| ID: mdl-24948207
ABSTRACT
PURPOSE OF THE STUDY Use of matched red blood cell (RBC) concentrates is imperative in patients with RBC allo-antibodies (Abs) and when platelet (PLT) specific allo-Abs are present additional difficulties occur for PLT transfusions. In order to evaluate the prevalence of the PLT and RBC allo-Abs association, a study on patients with PLT specific allo-Acs was performed. This association is not a rare event. PATIENTS AND METHODS:
In the database of a PLT immunohaematology laboratory, patients with PLT specific allo-Abs were selected and the presence and specificity of RBC allo-Abs was evaluated.RESULTS:
Six hundred and eighty seven patients (673 females, 14 males) with PLT specific allo-Abs were found. Six hundred and seventy-five patients (98.3%) had PLT specific allo-Abs with only one specificity. Anti-HPA-5b was the most frequent (539 cases). Twenty-nine (4.2%) patients had also RBC allo-Abs, including 27 females (93.1%) and two males. Seventy (58.6%) had RBC allo-Abs with only one specificity, 10 several and two unknown. Among the first, RBC allo-Abs directed against Rhesus blood group antigens were predominant (11 cases [64.7%]). Among the 29 patients with associated PLT and RBC allo-Abs, 15 (51.7%) were 50 or more years old and 14 (48.3%) under 50.CONCLUSION:
In PLT specific alloimmunized patients, detection of RBC alloimmunization is not a rare event. When RBC and PLT transfusions are required, the supply of matched RBC and PLT concentrates is more difficult.Palavras-chave
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MEDLINE
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Plaquetas
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Eritrócitos
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Isoanticorpos
Idioma:
Fr
Ano de publicação:
2014
Tipo de documento:
Article