Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation.

Siu, Ka Tat; Xu, Yanfei; Swartz, Kelsey L; Bhattacharyya, Mitra; Gurbuxani, Sandeep; Hua, Youjia; Minella, Alex C

Siu, Ka Tat; Xu, Yanfei; Swartz, Kelsey L; Bhattacharyya, Mitra; Gurbuxani, Sandeep; Hua, Youjia; Minella, Alex C.

Afiliação

Siu KT; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Xu Y; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Swartz KL; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Bhattacharyya M; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Gurbuxani S; Section of Hematopathology, Department of Pathology, University of Chicago Medical Center, Chicago, Illinois, USA.
Hua Y; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Minella AC; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA a-minella@northwestern.edu.

Mol Cell Biol ; 34(17): 3244-58, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24958101

Assuntos

Instabilidade Cromossômica/fisiologia; Ciclina E/genética; Ciclina E/metabolismo; Proteínas F-Box/genética; Proteínas F-Box/metabolismo; Células-Tronco Hematopoéticas/fisiologia; Linfoma de Células T/etiologia; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Substituição de Aminoácidos; Animais; Linhagem da Célula; Instabilidade Cromossômica/genética; Proteína 7 com Repetições F-Box-WD; Genes p53; Transplante de Células-Tronco Hematopoéticas; Células-Tronco Hematopoéticas/patologia; Linfoma de Células T/genética; Linfoma de Células T/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Estabilidade Proteica; Proteólise; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Linfoma de Células T / Ciclina E / Instabilidade Cromossômica / Ubiquitina-Proteína Ligases / Proteínas F-Box Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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