Impact of microparticle formulation approaches on drug burst release: a level A IVIVC.
J Microencapsul
; 31(7): 674-84, 2014.
Article
em En
| MEDLINE
| ID: mdl-24963960
ABSTRACT
AIM:
To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release.METHODS:
A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were compared; the in situ forming microparticle (ISM) and the emulsion-solvent evaporation (ESE) methods using an experimental design. The MPs obtained were compared according to their physical characterization, burst release and T80%. An in vivo pharmacokinetic study with in vitro-in vivo correlation (IVIVC) was also performed for the selected formula.RESULTS:
Both methods were able to sustain drug release for three weeks. ISM produced more porous particles and was not effective as ESE for controlling burst release. A good IVIVC (R(2) = 0.9755) was attained when injecting the selected formula into rats.CONCLUSION:
MPs prepared with ESE showed a minimum burst release and a level A IVIVC was obtained when administered to rats.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
/
Antipsicóticos
/
Clozapina
/
Ácido Láctico
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article