Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--II. Biological distributions of 99mTc-DMAD components isolated by anion exchange HPLC.
Int J Rad Appl Instrum B
; 16(3): 313-7, 1989.
Article
em En
| MEDLINE
| ID: mdl-2497091
ABSTRACT
HPLC isolated components of 99mTc(NaBH4)-DMAD mixtures exhibit significantly different biological properties than do analogous components of 99mTc(NaBH4)-MDP and 99mTc(NaBH4)-HEDP mixtures. Most importantly, 99mTc-DMAD components desorb from normal bone whereas analogous 99mTc-MDP and 99mTc-HEDP components do not. However, within an osteogenic rat model, an HPLC isolated 99mTc-DMAD component does not exhibit an unusually high abnormal/normal tibia uptake ratio.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Boroidretos
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Compostos de Organotecnécio
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Tecnécio
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Difosfonatos
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article