Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

Carlile, Graeme W; Robert, Renaud; Goepp, Julie; Matthes, Elizabeth; Liao, Jie; Kus, Bart; Macknight, Sean D; Rotin, Daniela; Hanrahan, John W; Thomas, David Y

Carlile, Graeme W; Robert, Renaud; Goepp, Julie; Matthes, Elizabeth; Liao, Jie; Kus, Bart; Macknight, Sean D; Rotin, Daniela; Hanrahan, John W; Thomas, David Y.

Afiliação

Carlile GW; Cystic Fibrosis Translational Research Center, Dept. of Biochemistry, McGill University, Montreal, Quebec H3G1Y6, Canada. Electronic address: graeme.carlile@mcgill.ca.
Robert R; Cystic Fibrosis Translational Research Center, Dept. of Physiology, McGill University, Montreal, Quebec H3G1Y6, Canada.
Goepp J; Cystic Fibrosis Translational Research Center, Dept. of Physiology, McGill University, Montreal, Quebec H3G1Y6, Canada.
Matthes E; Cystic Fibrosis Translational Research Center, Dept. of Physiology, McGill University, Montreal, Quebec H3G1Y6, Canada.
Liao J; Cystic Fibrosis Translational Research Center, Dept. of Physiology, McGill University, Montreal, Quebec H3G1Y6, Canada.
Kus B; Hospital for Sick Children, Dept. of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada.
Macknight SD; Cystic Fibrosis Translational Research Center, Dept. of Biochemistry, McGill University, Montreal, Quebec H3G1Y6, Canada.
Rotin D; Hospital for Sick Children, Dept. of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada.
Hanrahan JW; Cystic Fibrosis Translational Research Center, Dept. of Physiology, McGill University, Montreal, Quebec H3G1Y6, Canada.
Thomas DY; Cystic Fibrosis Translational Research Center, Dept. of Biochemistry, McGill University, Montreal, Quebec H3G1Y6, Canada.

J Cyst Fibros ; 14(1): 16-25, 2015 Jan.

Article em En | MEDLINE | ID: mdl-24974227

Assuntos

Movimento Celular/efeitos dos fármacos; Inibidores de Ciclo-Oxigenase/farmacologia; Regulador de Condutância Transmembrana em Fibrose Cística/efeitos dos fármacos; Fibrose Cística/tratamento farmacológico; Ibuprofeno/farmacologia; Animais; Movimento Celular/genética; Células Cultivadas/efeitos dos fármacos; Fibrose Cística/genética; Regulador de Condutância Transmembrana em Fibrose Cística/genética; Modelos Animais de Doenças; Humanos; Camundongos; Camundongos Endogâmicos CFTR; Mutação; Transporte Proteico/efeitos dos fármacos; Transporte Proteico/genética; RNA Interferente Pequeno/genética; Reprodutibilidade dos Testes; Sensibilidade e Especificidade

Palavras-chave

Cystic fibrosis; NSAID; Protein folding; Protein trafficking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Movimento Celular / Ibuprofeno / Inibidores de Ciclo-Oxigenase / Regulador de Condutância Transmembrana em Fibrose Cística / Fibrose Cística Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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