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A unified nomenclature and amino acid numbering for human PTEN.
Pulido, Rafael; Baker, Suzanne J; Barata, Joao T; Carracedo, Arkaitz; Cid, Victor J; Chin-Sang, Ian D; Davé, Vrushank; den Hertog, Jeroen; Devreotes, Peter; Eickholt, Britta J; Eng, Charis; Furnari, Frank B; Georgescu, Maria-Magdalena; Gericke, Arne; Hopkins, Benjamin; Jiang, Xeujun; Lee, Seung-Rock; Lösche, Mathias; Malaney, Prerna; Matias-Guiu, Xavier; Molina, María; Pandolfi, Pier Paolo; Parsons, Ramon; Pinton, Paolo; Rivas, Carmen; Rocha, Rafael M; Rodríguez, Manuel S; Ross, Alonzo H; Serrano, Manuel; Stambolic, Vuk; Stiles, Bangyan; Suzuki, Akira; Tan, Seong-Seng; Tonks, Nicholas K; Trotman, Lloyd C; Wolff, Nicolas; Woscholski, Rudiger; Wu, Hong; Leslie, Nicholas R.
Afiliação
  • Pulido R; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. BioCruces Health Research Institute, Barakaldo, Spain. rpulidomurillo@gmail.com.
  • Baker SJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, USA.
  • Barata JT; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
  • Carracedo A; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.
  • Cid VJ; Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.
  • Chin-Sang ID; Department of Biology, Queen's University, Kingston, Ontario, Canada.
  • Davé V; Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.
  • den Hertog J; Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands.
  • Devreotes P; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Eickholt BJ; Charité-Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.
  • Eng C; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  • Furnari FB; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Georgescu MM; The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
  • Gericke A; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
  • Hopkins B; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Jiang X; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Lee SR; Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Lösche M; Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
  • Malaney P; Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.
  • Matias-Guiu X; Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain.
  • Molina M; Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.
  • Pandolfi PP; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.
  • Parsons R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Pinton P; Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
  • Rivas C; Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spai
  • Rocha RM; Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil.
  • Rodríguez MS; Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain.
  • Ross AH; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Serrano M; Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  • Stambolic V; Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Stiles B; Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
  • Suzuki A; Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan.
  • Tan SS; Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.
  • Tonks NK; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Trotman LC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Wolff N; Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France.
  • Woscholski R; Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK.
  • Wu H; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Leslie NR; Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK.
Sci Signal ; 7(332): pe15, 2014 Jul 01.
Article em En | MEDLINE | ID: mdl-24985344
ABSTRACT
The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Códon de Iniciação / Bases de Dados de Proteínas / PTEN Fosfo-Hidrolase / Aminoácidos Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Códon de Iniciação / Bases de Dados de Proteínas / PTEN Fosfo-Hidrolase / Aminoácidos Idioma: En Ano de publicação: 2014 Tipo de documento: Article