Downregulation of angiogenesis factors, VEGF and PDGF, after rapid IgE desensitization and oral immunotherapy in children with food allergy.
Biomed Res Int
; 2014: 372567, 2014.
Article
em En
| MEDLINE
| ID: mdl-24995287
ABSTRACT
BACKGROUND:
Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy.METHODS:
We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th1, Th2, Treg, and Th17 cytokines were also monitored.RESULTS:
Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later.CONCLUSION:
The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Fator de Crescimento Derivado de Plaquetas
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Fator A de Crescimento do Endotélio Vascular
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Hipersensibilidade Alimentar
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Proteínas do Leite
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article