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Lineage II of Southeast Asian/American DENV-2 is associated with a severe dengue outbreak in the Peruvian Amazon.
Williams, Maya; Mayer, Sandra V; Johnson, William L; Chen, Rubing; Volkova, Evgeniya; Vilcarromero, Stalin; Widen, Steven G; Wood, Thomas G; Suarez-Ognio, Luis; Long, Kanya C; Hanley, Kathryn A; Morrison, Amy C; Vasilakis, Nikos; Halsey, Eric S.
Afiliação
  • Williams M; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Mayer SV; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Johnson WL; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Chen R; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Volkova E; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Vilcarromero S; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Widen SG; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Wood TG; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Suarez-Ognio L; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Long KC; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Hanley KA; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Morrison AC; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Vasilakis N; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
  • Halsey ES; Department of Virology, US Naval Medical Research Unit No. 6, Lima, Peru; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Department o
Am J Trop Med Hyg ; 91(3): 611-20, 2014 Sep.
Article em En | MEDLINE | ID: mdl-25002298
ABSTRACT
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Genoma Viral / Aedes / Dengue Grave / Vírus da Dengue / Insetos Vetores Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Genoma Viral / Aedes / Dengue Grave / Vírus da Dengue / Insetos Vetores Idioma: En Ano de publicação: 2014 Tipo de documento: Article